The effect of Sub-Minimum Inhibitory Concentration (S-MIC) of ciprofloxacin & ampicillin on hemolysin activity of Escherichia coli SA Havaei, M Satari, M Oshaghi, A Hashemi Shahraki IJMM 2008; 2(1):53-58 ICID: 873191
Article type: Original article
IC™ Value: 3.25
Abstract provided by Publisher
Background and objectives: Sub-minimum inhibitory concentration (S - MIC) can induce changes in morphology, virulence factors and biochemical properties of bacterial pathogens. The goal of this study is to determine the Sub-MIC effect of ciprofloxacin and ampicillin on the haemotytic activity of E. coli.
Material and Methods:Two clinical isolates of E. coli with high heamolytic activity was selected. Changes in haemolytic activity of the isolates was assessed after exposing them to MIC and Sub-MIC of ciprofloxacin and ampicillin.
Results: Ciprofloxacin decreased haemolytic activity at 1/2, 1/4 and 1/8 Sub-Mic, whereas ampicillin showed no effect on haemolytic activity .
Conclusion: We conclude that Sub-MIC concentrations of ciprofloxacin decreased the haemolytic activity of E. coli, wherease ampicillin had no such effect.
Keywords: E. coli, Haemolytic activity, Ampicillin, Ciprofloxacin,